Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis.

@article{Kaur2016MutantSM,
  title={Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis.},
  author={S. Kaur and S. McKeown and Shazia Rashid},
  journal={Gene},
  year={2016},
  volume={577 2},
  pages={
          109-18
        }
}
Amyotrophic lateral sclerosis (ALS) is a neural disorder that causes death of the motor neurons in the brain and spinal cord; this affects the voluntary muscles and gradually leads to paralysis of the whole body. Most ALS cases are sporadic, though about 5-10% are familial. ALS is caused by multiple factors including mutation in any one of a number of specific genes, one of the most frequently affected is superoxide dismutase (SOD) 1. Alterations in SOD 1 have been linked with several variants… Expand
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