Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis

@inproceedings{Chang2017MutantRR,
  title={Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis},
  author={Huaiguang Chang and Yue Wang and Haochen Liu and Xu Nan and Singwai Wong and Saihui Peng and Yajuan Gu and Hongshan Zhao and Hai-lan Feng},
  booktitle={Cell Death & Disease},
  year={2017}
}
Regulation of microRNAs (miRNA) has been extensively investigated in diseases; however, little is known about the roles of miRNAs in cleidocranial dysplasia (CCD). The aim of the present study was to investigate the potential involvement of miRNAs in CCD. In vitro site-directed mutagenesis was performed to construct three mutant Runx2 expression vectors… CONTINUE READING