Mutant PIK 3 CA promotes cell growth and invasion of human cancer cells

  title={Mutant PIK 3 CA promotes cell growth and invasion of human cancer cells},
  author={Yardena Samuels and Luis A Diaz and Oleg Schmidt-Kittler and Jordan M. Cummins and Laura Delong and Ian Cheong and Carlo Rago and David Leonard Huso and Christoph Lengauer and Kenneth W. Kinzler and Bert Vogelstein and Victor E. Velculescu},
PIK3CA is mutated in diverse human cancers, but the functional effects of these mutations have not been defined. To evaluate the consequences of PIK3CA alterations, the two most common mutations were inactivated by gene targeting in colorectal cancer (CRC) cells. Biochemical analyses of these cells showed that mutant PIK3CA selectively regulated the phosphorylation of AKT and the forkhead transcription factors FKHR and FKHRL1. PIK3CA mutations had little effect on growth under standard… CONTINUE READING
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