Mutant Mice (quaking and Jimpy) with Deficient Myelination in the Central Nervous System.

@article{Sidman1964MutantM,
  title={Mutant Mice (quaking and Jimpy) with Deficient Myelination in the Central Nervous System.},
  author={Richard L. Sidman and Margaret M Dickie and Stanley H. Appel},
  journal={Science},
  year={1964},
  volume={144 3616},
  pages={309-11}
}
Two mutant mice with deficient myelination are described. Quaking is a new autosomal recessive mutant mouse with marked tremor of the hindquarters. The mice eat, swim, breed, and nurse well even though the entire central nervous system is very deficient in myelin by histological and chemical criteria. Myelin formation is impaired; no destruction is seen. Peripheral nerves are myelinated. Jimpy, a known sex-linked mutation, has similar but more severe symptoms and similar pathology, with the… CONTINUE READING

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