Mutant MHC class I molecules define interactions between components of the peptide-loading complex.

@article{Paquet2002MutantMC,
  title={Mutant MHC class I molecules define interactions between components of the peptide-loading complex.},
  author={M{\'e}lissa Paquet and David Brian Williams},
  journal={International immunology},
  year={2002},
  volume={14 4},
  pages={
          347-58
        }
}
Class I histocompatibility molecules, consisting of a heavy chain, beta2-microglobulin and peptide, are assembled in the endoplasmic reticulum (ER) with the assistance of several molecular chaperones and accessory proteins. Peptide binding occurs when assembling class I molecules associate with a loading complex consisting of the transporter associated with antigen processing (TAP) peptide transporter, tapasin, ERp57 and calreticulin (CRT)/calnexin. To assess the physical organization of this… CONTINUE READING
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