Mutant KRAS, chromosomal instability and prognosis in colorectal cancer.

@article{Castagnola2005MutantKC,
  title={Mutant KRAS, chromosomal instability and prognosis in colorectal cancer.},
  author={Patrizio Castagnola and Walter Giaretti},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1756 2},
  pages={115-25}
}
The RAS gene family provides a global effect on gene expression by encoding small GTP-binding proteins which act as molecular switches connecting extracellular signals with nuclear transcription factors. While wild type RAS proteins are switched off shortly after activation, mutant RAS proteins remain constitutively activated leading to complex interactions among their downstream effectors. For some human tumor types, these interactions were shown to contribute to cancer genesis and progression… CONTINUE READING