Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?

@article{Rondard2001MutantGP,
  title={Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?},
  author={Philippe Rondard and Taroh Iiri and Sankaranarayanan Srinivasan and Er Meng and Toshiro Fujita and Henry R. Bourne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 11},
  pages={6150-5}
}
How receptors catalyze exchange of GTP for GDP bound to the Galpha subunit of trimeric G proteins is not known. One proposal is that the receptor uses the G protein's betagamma heterodimer as a lever, tilting it to pull open the guanine nucleotide binding pocket of Galpha. To test this possibility, we designed a mutant Galpha that would bind to betagamma in the tilted conformation. To do so, we excised a helical turn (four residues) from the N-terminal region of alpha(s), the alpha subunit of G… CONTINUE READING
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