Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

@article{Kaykas2004MutantF4,
  title={Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization},
  author={Ajamete Kaykas and Julia A. Yang-Snyder and Madeleine H{\'e}roux and Kavita V. Shah and Michel Bouvier and Randall T. Moon},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={52-58}
}
nt signalling pathways regulate cell proliferation, cell fate and morphogenetic movements. Here, we demonstrate that the Frizzled (Fz) family of Wnt receptors, similarly to G-protein-coupled receptors (GPCRs), form specific homo- and hetero-oligomers. Two lines of evidence suggest that oligomerization occurs in the endoplasmic reticulum: first, a mutant allele of Fz4, encoding a truncated protein that is retained in the endoplasmic reticulum, is linked to the autosomal-dominant retinal… CONTINUE READING

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