Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

  title={Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders},
  author={Mayumi Naramura and Scott A. Nadeau and Bhopal C. Mohapatra and Gulzar Ahmad and Chandrani Mukhopadhyay and Martin Sattler and Srikumar M. Raja and Amarnath Natarajan and Vimla Band and Hamid Band},
Casitas B-lineage lymphoma (Cbl) family proteins are evolutionarily-conserved attenuators of protein tyrosine kinase (PTK) signaling. Biochemical analyses over the past two decades have firmly established that the negative regulatory functions of Cbl proteins are mediated through their ability to facilitate ubiquitination and thus promote degradation of PTKs. As aberrant activation of PTKs is frequently associated with oncogenesis, it has long been postulated that loss of normal Cbl functions… CONTINUE READING
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Highthroughput fluorescence polarization assay to identify inhibitors of casitas B-lineage lymphoma(tyrosine kinase binding)-protein tyrosine kinase interactions

  • EA Kumar, CD Charvet, GL Lokesh, A. Natarajan
  • Anal Biochem. 2010 Dec 1. [Epub ahead of print]
  • 2010
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