Mutant Caldesmon lacking cdc2 phosphorylation sites delays M-phase entry and inhibits cytokinesis.

Abstract

Caldesmon is phosphorylated by cdc2 kinase during mitosis, resulting in the dissociation of caldesmon from microfilaments. To understand the physiological significance of phosphorylation, we generated a caldesmon mutant replacing all seven cdc2 phosphorylation sites with Ala, and examined effects of expression of the caldesmon mutant on M-phase progression… (More)

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@article{Yamashiro2001MutantCL, title={Mutant Caldesmon lacking cdc2 phosphorylation sites delays M-phase entry and inhibits cytokinesis.}, author={S. M. Yamashiro and Hueylan Chern and Yuki Yamakita and Fumiko Matsumura}, journal={Molecular biology of the cell}, year={2001}, volume={12 1}, pages={239-50} }