Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model.

@article{Nabeshima2017MutantCP,
  title={Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model.},
  author={Akira Nabeshima and Jukka Sakari Pajarinen and Tzu-hua Lin and Xinyi Jiang and Emmanuel Gibon and Luis Alberto Cordova and Florence Loi and Laura Y. Lu and Eemeli J{\"a}msen and Kensuke Egashira and Fan Yang and Zhenyu Yao and Stuart Barry Goodman},
  journal={Biomaterials},
  year={2017},
  volume={117},
  pages={1-9}
}
Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the most important chemokine regulating trafficking of monocyte/macrophages in particle-induced inflammation. 7ND recombinant protein is a… CONTINUE READING