Mutagenicity studies with o-tolidine and 4,4'-tetramethyldiaminodiphenylmethane.

  title={Mutagenicity studies with o-tolidine and 4,4'-tetramethyldiaminodiphenylmethane.},
  author={D H Waalkens and H. F. P. Joosten and T D Yih and A. F. Th. Hoekstra},
  journal={Mutation research},
  volume={89 3},
This paper confirms the mutagenicity of 2 carcinogenic chemicals, o-tolidine and 4,4'-tetramethyldiaminodiphenylmethane (TDDM). o-Tolidine and TDDM were both tested in the Salmonella/mammalian-microsome test and in the sister-chromatid exchange (SCE) test with rabbit lymphocytes in vitro. The number of revertants was increased in the presence of S9 mix by o… CONTINUE READING