Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone.

@article{ODonoghue1988MutagenicitySO,
  title={Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone.},
  author={John L O'Donoghue and Stephen Haworth and Rodger D. Curren and Peter Kirby and Timothy M. Lawlor and Edmund J. Moran and Robert Dixon Phillips and Dana Putnam and A M Rogers-Back and Ronald S Slesinski},
  journal={Mutation research},
  year={1988},
  volume={206 2},
  pages={149-61}
}
3 ketone solvents (methyl ethyl ketone (MEK), methyl isobutyl ketone (MiBK), and isophorone) were tested for potential genotoxicity. The assays of MEK and MiBK included the Salmonella/microsome (Ames) assay, L5178Y/TK+/- mouse lymphoma (ML) assay, BALB/3T3 cell transformation (CT) assay, unscheduled DNA synthesis (UDS) assay, and micronucleus (MN) assay. Only the ML, UDS, and MN assays were conducted on samples of isophorone. No genotoxicity was found for MEK or isophorone. The presence of a… CONTINUE READING