Mutagenicity studies of benzidine and its analogs: structure-activity relationships.

@article{Chung2000MutagenicitySO,
  title={Mutagenicity studies of benzidine and its analogs: structure-activity relationships.},
  author={K. Chung and S. Chen and T. Wong and Y. Li and C. Wei and M. Chou},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={56 2},
  pages={
          351-6
        }
}
  • K. Chung, S. Chen, +3 authors M. Chou
  • Published 2000
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
The Ames Salmonella/microsome assay was employed to test the mutagenicity of benzidine and its analogs using strains TA98 and TA100 in the presence and absence of Aroclor 1254-induced rat S9 mix. 3,3'-Dichlorobenzidine-2HCl and 4,4'-dinitro-2-biphenylamine were directly mutagenic to TA98, while 4,4'-dinitro-2-biphenylamine was directly mutagenic to both TA98 and TA100 in the absence of S9 mix. 2-Aminobiphenyl, 3-aminobiphenyl, and 3,3'-5,5'-tetramethylbenzidine were not mutagenic in either… Expand
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