Mutagenicity studies of benzidine and its analogs: structure-activity relationships.
@article{Chung2000MutagenicitySO, title={Mutagenicity studies of benzidine and its analogs: structure-activity relationships.}, author={K. T. Chung and S C Chen and T Y Wong and Y S Li and C. I. Wei and Ming W. Chou}, journal={Toxicological sciences : an official journal of the Society of Toxicology}, year={2000}, volume={56 2}, pages={ 351-6 } }
The Ames Salmonella/microsome assay was employed to test the mutagenicity of benzidine and its analogs using strains TA98 and TA100 in the presence and absence of Aroclor 1254-induced rat S9 mix. 3,3'-Dichlorobenzidine-2HCl and 4,4'-dinitro-2-biphenylamine were directly mutagenic to TA98, while 4,4'-dinitro-2-biphenylamine was directly mutagenic to both TA98 and TA100 in the absence of S9 mix. 2-Aminobiphenyl, 3-aminobiphenyl, and 3,3'-5,5'-tetramethylbenzidine were not mutagenic in either…
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