Mutagenicity studies of benzidine and its analogs: structure-activity relationships.

  title={Mutagenicity studies of benzidine and its analogs: structure-activity relationships.},
  author={K. T. Chung and S C Chen and T Y Wong and Y S Li and C. I. Wei and Ming W. Chou},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={56 2},
  • K. Chung, S. C. Chen, M. Chou
  • Published 1 August 2000
  • Chemistry, Biology
  • Toxicological sciences : an official journal of the Society of Toxicology
The Ames Salmonella/microsome assay was employed to test the mutagenicity of benzidine and its analogs using strains TA98 and TA100 in the presence and absence of Aroclor 1254-induced rat S9 mix. 3,3'-Dichlorobenzidine-2HCl and 4,4'-dinitro-2-biphenylamine were directly mutagenic to TA98, while 4,4'-dinitro-2-biphenylamine was directly mutagenic to both TA98 and TA100 in the absence of S9 mix. 2-Aminobiphenyl, 3-aminobiphenyl, and 3,3'-5,5'-tetramethylbenzidine were not mutagenic in either… 

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