Mutagenicity of urine from rats after administration of 2,4-diaminoanisole: the effect of microsomal enzyme inducers.

@article{Reddy1980MutagenicityOU,
  title={Mutagenicity of urine from rats after administration of 2,4-diaminoanisole: the effect of microsomal enzyme inducers.},
  author={T. Reddy and T. Benjamin and P. H. Grantham and E. Weisburger and S. Thorgeirsson},
  journal={Mutation research},
  year={1980},
  volume={79 4},
  pages={
          307-17
        }
}
Ring 14C-labelled 2,4-diaminoanisole disulfate was administered to rats pretreated with the microsomal inducers phenobarbital (PB), beta-naphthoflavone (BNF), 3-methylcholanthrene (MC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The 24-h urine from rats pretreated with PB showed a 2-fold increase in revertant rate over the corresponding control as measured by the Ames Salmonella test system. Pretreatment of rats with BNF, MC or TCDD decreased the mutagenicity of urine by about 70% when an… Expand
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References

SHOWING 1-8 OF 8 REFERENCES
Metabolic activation of 2,4-diamino-anisole, a hair-dye component--I. Role of cytochrome p-450 metabolism in mutagenicity in vitro.
TLDR
It is suggested that metabolic activation of 2, 4-diaminoanisole to the hydroxylamine(s) may be the underlying reaction for the formation of mutagenic intermediates. Expand
Mutagenic activation of N-hydroxy-2-acetylaminofluorene in the Salmonella test system: the role of deacetylation by liver and kidney fractions from mouse and rat.
TLDR
The data indicate that deacetylation is the most important step in the mutagenic activation of N-hydroxy-2-acetylaminofluorene by mouse and rat liver and kidney fractions and that the arylnitrenium ion is the electrophilic species interacting with the bacterial DNA, resulting in the frameshift mutation. Expand
Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450.
A bacterial mutagenesis assay and genetic differences in microsomal CO-binding cytochromes were combined in vitro to evaluate the metabolic activation of several known carcinogens to frameshiftExpand
Metabolism of the dyestuff intermediate 2,4-diaminoanisole in the rat.
TLDR
1.2HCl administered intraperitoneally to rats is excreted chiefly via the urine (79 and 85% of the dose in 24 and 48 h, respectively) and the isotope in the faeces was 2,4-Diamino[ring-U-14C]anisole. Expand
Genetic differences in 2-acetylaminofluorene mutagenicity in vitro associated with mouse hepatic aryl hydrocarbon hydroxylase activity induced by polycyclic aromatic compounds.
TLDR
It is suggested that the rate-limiting step of 2-acetylaminofluorene mutagenesis is its activation by cytochrome P1450 to the N -hydroxy derivative, which is metabolized further to a much more mutagenic intermediate by a reaction independent of cy tochrome P 1450-possibly a deacetylation reaction. Expand
Hair dyes are mutagenic: identification of a variety of mutagenic ingredients.
TLDR
It is shown here that 89% (150/169) of commercial oxidative-type (hydrogen peroxide) hair dye formulations are mutagenic in this test, a sensitive bacterial test for detecting carcinogens as mutagens. Expand
Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.
TLDR
The methods described include the standard plate test, the use and storage of the bacterial tester strains, preparation and use of the liver homogenates, and the methods of inducing the rats for elevated microsomal enzyme activity. Expand
Protein measurement with the Folin phenol reagent.
TLDR
Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein. Expand