Mutagenicity of ptaquiloside, the carcinogen in bracken, and its related illudane-type sesquiterpenes. II. Chromosomal aberration tests with cultured mammalian cells.

@article{Matsuoka1989MutagenicityOP,
  title={Mutagenicity of ptaquiloside, the carcinogen in bracken, and its related illudane-type sesquiterpenes. II. Chromosomal aberration tests with cultured mammalian cells.},
  author={Atsuko Matsuoka and Akira Hirosawa and Shunji Natori and Shogo Iwasaki and Toshio Sofuni and Motoi Ishidate},
  journal={Mutation research},
  year={1989},
  volume={215 2},
  pages={179-85}
}
The chromosomal aberration test using a Chinese hamster lung cell line (CHL) was carried out on ptaquiloside and its related compounds, hypoloside B, hypoloside C, illudin M and illudin S. Ptaquiloside induced chromosomal aberrations at doses as low as 4.5 micrograms/ml (0.0113 mM). The clastogenic effect was pH-dependent. The same activity was observed at a 90-fold higher dose at pH 5.3 in the culture medium compared with the activity at pH 7.4 or pH 8.0. Both hypoloside B and hypoloside C… CONTINUE READING

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