Mutagenicity of metabolic oxygen radicals in mammalian cell cultures.

Abstract

Reactive oxygen species produced by normal cellular metabolism have been considered to play a causative role in spontaneously occurring genomic instability and carcinogenesis. To study the genotoxic consequences of an enhanced flux of metabolically produced reactive oxygen species, cells may be exposed to hyperoxia (elevated concentrations of oxygen), a… (More)

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@article{Gille1994MutagenicityOM, title={Mutagenicity of metabolic oxygen radicals in mammalian cell cultures.}, author={Johan J. P. Gille and Cees van Berkel and Hans Joenje}, journal={Carcinogenesis}, year={1994}, volume={15 12}, pages={2695-9} }