Mutagenicity of metabolic oxygen radicals in mammalian cell cultures.

  title={Mutagenicity of metabolic oxygen radicals in mammalian cell cultures.},
  author={Johannes J. P. Gille and Carola G. M. van Berkel and Hans Joenje},
  volume={15 12},
Reactive oxygen species produced by normal cellular metabolism have been considered to play a causative role in spontaneously occurring genomic instability and carcinogenesis. To study the genotoxic consequences of an enhanced flux of metabolically produced reactive oxygen species, cells may be exposed to hyperoxia (elevated concentrations of oxygen), a condition known to generate high levels of microscopically visible chromosomal damage. Here we assess the mutagenic potential of normobaric… CONTINUE READING