Mutagenicity of hydralazine in mammalian cells and bacteria.

@article{Mcqueen1993MutagenicityOH,
  title={Mutagenicity of hydralazine in mammalian cells and bacteria.},
  author={Charlene A. Mcqueen and B M Way and S M Queener},
  journal={Toxicology and applied pharmacology},
  year={1993},
  volume={118 1},
  pages={
          135-8
        }
}
The genotoxicity of hydralazine (HDZ), an antihypertensive agent, was evaluated in mammalian cells and bacteria. The formation of mutants at the hypoxanthine guanine phosphoribosyl transferase locus in an adult rat liver cell line ARL 18 was determined. Bacterial mutagenicity was assessed in Salmonella typhimurium strains TA100 and TA102. The latter strain was chosen because it has A:T bases at the reversion site and HDZ has been reported to interact with thymidine. HDZ was mutagenic to ARL 18… 
BIOTRANSFORMATION OF HYDRAZINE DERVATIVES IN THE MECHANISM OF TOXICITY.
  • B. Sinha, R. Mason
  • Biology, Chemistry
    Journal of drug metabolism & toxicology
  • 2014
TLDR
This review examines various metabolic pathways of hydrazines for the formation of reactive species that bind to cellular macromolecules and lead to cellular dysfunction.