Mutagenicity of diagnostic and therapeutical doses of radiopharmaceutical iodine-131 in Wistar rats.

@article{Dsman2011MutagenicityOD,
  title={Mutagenicity of diagnostic and therapeutical doses of radiopharmaceutical iodine-131 in Wistar rats.},
  author={Elis{\^a}ngela D{\"u}sman and Alessandra Paim Berti and Rosinete Gonçalves Mariucci and Nilson Benedito Lopes and Veronica Elisa Pimenta Vicentini},
  journal={Radiation and environmental biophysics},
  year={2011},
  volume={50 4},
  pages={579-84}
}
Iodine-131 ((131)I) is a radioisotope used for the diagnosis and treatment of thyroidal disorders such as hyperthyroidism and cancer. During its decay, (131)I emits beta particles and gamma rays; its physical half-life is 8 days, and it is accumulated preferentially in the thyroid tissue. This study aimed to evaluate the cytotoxicity and mutagenicity of diagnostic and therapeutic doses of (131)I using bone marrow cells of rats treated in vivo in a test system with a single dose by gavage… CONTINUE READING