Mutagenicity of benzo(e)pyrene and triphenylene tetrahydroepoxides and diol-epoxides in bacterial and mammalian cells.


bon. Recent studies have shown that little if any B(e)P3(Chart i ) is metabolized to B(e)P 9,i 0-dihydrodiol by cultured hamster embryo cells (i 5) and rat liver microsomes,4 and little if any B(e)P dihydrodiol is metabolized to its bay-region diol-epoxide diastereomers by rat liver microsomes (i 2, 28). While the reason for the negligible amount of B(e)P 9… (More)