Mutagenicity of benzo(a)pyrenyl‐1‐sulfate in the Ames test

@article{Irwin1992MutagenicityOB,
  title={Mutagenicity of benzo(a)pyrenyl‐1‐sulfate in the Ames test},
  author={S. E. Irwin and G. Kwei and G. Blackburn and R. Thurman and F. Kauffman},
  journal={Environmental and Molecular Mutagenesis},
  year={1992},
  volume={19}
}
Comparison of the mutagenicity of nine isomeric benzo(a)pyrenyl [B(a)P] phenols conjugated with either sulfate or glucuronide was carried out using strain Salmonella typhimurium TA98. Of the nine conjugates tested, only B(a)P‐1‐sulfate was mutagenic. Accordingly, the mutagenicity of B(a)P‐1‐sulfate was compared with that of B(a)P and 1‐hydroxybenzo(a)pyrene [B(a)P‐1‐OH] in the presence and absence of rat lung S9 and Aroclor‐induced liver S9 with and with out an NADPH‐generating system. B(a)P‐1… Expand
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