Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems.

@article{Reid1984MutagenicityOA,
  title={Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems.},
  author={Terinia Reid and Katherine Morton and Ching Yung Wang and Charles A. King},
  journal={Environmental mutagenesis},
  year={1984},
  volume={6 5},
  pages={705-17}
}
The mutagenic activity of a group of diazo dyes based on benzidine and its congeners was compared following metabolic activation of the dyes through sequential reduction and oxidation. The dyes were reduced by incubating them with either a suspension of rat cecal flora or a hamster S9 mix supplemented with flavin mononucleotide. The products of dye reduction were then subjected to oxidative metabolism by either Aroclor-induced rat liver S9 or by hamster liver S9; the resultant mutagenic… CONTINUE READING