Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species.

@article{Hei1998MutagenicityOA,
  title={Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species.},
  author={Tom K. Hei and S. X. Liu and Charles A. Waldren},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 14},
  pages={
          8103-7
        }
}
Arsenite, the trivalent form of arsenic present in the environment, is a known human carcinogen that lacked mutagenic activity in bacterial and standard mammalian cell mutation assays. We show herein that when evaluated in an assay (AL cell assay), in which both intragenic and multilocus mutations are detectable, that arsenite is in fact a strong dose-dependent mutagen and that it induces mostly large deletion mutations. Cotreatment of cells with the oxygen radical scavenger dimethyl sulfoxide… CONTINUE READING

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