Mutagenicity of acrolein and acrolein-induced DNA adducts

  title={Mutagenicity of acrolein and acrolein-induced DNA adducts},
  author={X. Liu and M. Zhu and J. Xie},
  journal={Toxicology Mechanisms and Methods},
  pages={36 - 44}
  • X. Liu, M. Zhu, J. Xie
  • Published 2010
  • Chemistry, Medicine
  • Toxicology Mechanisms and Methods
  • Acrolein mutagenicity relies on DNA adduct formation. Reaction of acrolein with deoxyguanosine generates α-hydroxy-1, N2-propano-2′-deoxyguanosine (α-HOPdG) and γ-hydroxy-1, N2-propano-2′-deoxyguanosine (γ-HOPdG) adducts. These two DNA adducts behave differently in mutagenicity. γ-HOPdG is the major DNA adduct and it can lead to interstrand DNA-DNA and DNA-peptide/protein cross-links, which may induce strong mutagenicity; however, γ-HOPdG can be repaired by some DNA polymerases complex and… CONTINUE READING
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