Mutagenicity of AH26 in an in vitro mammalian cell mutation assay.

@article{Schweikl1995MutagenicityOA,
  title={Mutagenicity of AH26 in an in vitro mammalian cell mutation assay.},
  author={Helmut Schweikl and Gottfried Schmalz and H Stimmelmayr and Benjamin S Bey},
  journal={Journal of endodontics},
  year={1995},
  volume={21 8},
  pages={407-10}
}
The mutagenic activity of the root canal sealer AH26 was tested in the V79/hprt mammalian cell mutation assay. AH26 was mixed and eluted immediately after mixing or after setting times of 24 h or 7 days. Different amounts of dimethyl sulfoxide or physiological saline eluates were then tested for mutagenicity. Eluates of mixed AH26 were toxic and mutagenic, and both effects strongly depended on the setting time. The number of mutants after exposure to eluates of unset AH26 was enhanced… CONTINUE READING

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