Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed.

@article{Monien2012MutagenicityO5,
  title={Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed.},
  author={Bernhard Hans Monien and Wolfram Engst and Gitte Barknowitz and Albrecht Seidel and Hansruedi Glatt},
  journal={Chemical research in toxicology},
  year={2012},
  volume={25 7},
  pages={1484-92}
}
5-Hydroxymethylfurfural (HMF), a heterocyclic product of the Maillard reaction, is a ubiquitous food contaminant. It has demonstrated hepatocarcinogenic activity in female mice. This effect may originate from sulfo conjugation of the benzylic alcohol yielding 5-sulfooxymethylfurfural (SMF), which is prone to react with DNA via nucleophilic substitution. Indeed, we showed that HMF induces gene mutations in Chinese hamster V79 cells engineered for the expression of human (h) sulfotransferase… CONTINUE READING

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