Corpus ID: 44689160

Mutagenicity and cytotoxicity of benzo(a)pyrene arene oxides, phenols, quinones, and dihydrodiols in bacterial and mammalian cells.

@article{Wislocki1976MutagenicityAC,
  title={Mutagenicity and cytotoxicity of benzo(a)pyrene arene oxides, phenols, quinones, and dihydrodiols in bacterial and mammalian cells.},
  author={P. Wislocki and A. Wood and R. Chang and W. Levin and H. Yagi and O. Hernandez and P. Dansette and D. M. Herina and A. Conney},
  journal={Cancer research},
  year={1976},
  volume={36 9 pt.1},
  pages={
          3350-7
        }
}
Twenty-nine benzo(a)pyrene derivatives were tested for mutagenic acitivity without metabolic activation in Salmonella typhimurium strains TA98, TA100, and TA1538 and in Chinese hamster V79 cells. The compounds studied included 4 arene oxides, all 12 isomeric phenols, 5 quinones, and 8 dihydrodiols. Benzo(a)pyrene 4,5-oxide was the most mutagenic of the compounds tested in both the bacterial and mammalian systems. The other arene oxides [benzo(a)pyrene 7,8-, 9,10-, and 11,12-oxides] were only… Expand
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