Mutagenicity and chemical reactivity of epoxidic intermediates of the isoprene metabolism and other structurally related compounds.

@article{Gervasi1985MutagenicityAC,
  title={Mutagenicity and chemical reactivity of epoxidic intermediates of the isoprene metabolism and other structurally related compounds.},
  author={Pier Giovanni Gervasi and Lorenzo Citti and Monte Del Monte and Vincenzo Longo and D. Benetti},
  journal={Mutation research},
  year={1985},
  volume={156 1-2},
  pages={77-82}
}
The mutagenic activities of the epoxidic intermediates of the isoprene biotransformation were investigated using Salmonella typhimurium and compared with those of other structurally related epoxides. The compound 2-methyl-1,2,3,4-diepoxybutane, chemically analogous to the well known carcinogenic 1,2,3,4-diepoxybutane, was found to be as mutagenic as the latter. Moreover, the mutagenic activities of oxiranes were correlated to their alkylating powers towards nicotinamide and to their half-lives… CONTINUE READING

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