Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green.

@article{Culp2002MutagenicityAC,
  title={Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green.},
  author={Sandra J. Culp and Frederick A Beland and Robert H. Heflich and Robert W. Benson and Lonnie R. Blankenship and Peggy J. Webb and Paul W. Mellick and Ronald W Trotter and Sharon D. Shelton and Kevin J. Greenlees and Mugimane G. Manjanatha},
  journal={Mutation research},
  year={2002},
  volume={506-507},
  pages={
          55-63
        }
}
Leucomalachite green is a persistent and prevalent metabolite of malachite green, a triphenylmethane dye that has been used widely as an antifungal agent in the fish industry. Concern over the use of malachite green is due to the potential for consumer exposure, evidence suggestive of tumor promotion in rodent liver, and suspicion of carcinogenicity based on structure-activity relationships. Our previous study indicated that feeding rodents malachite or leucomalachite green resulted in a dose… CONTINUE READING
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