Mutagenicity and antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays

@inproceedings{Resende2012MutagenicityAA,
  title={Mutagenicity and antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays},
  author={Fl{\'a}via Aparecida Resende and Lilian Cristina Barbosa and Denise Crispim Tavares and Mariana Santoro de Camargo and Karen Cristina de Souza Rezende and M{\'a}rcio Luis de Andrade e Silva and Eliana Aparecida Varanda},
  booktitle={BMC complementary and alternative medicine},
  year={2012}
}
BACKGROUND The dibenzylbutyrolactone lignan (-)-hinokinin (HK) was derived by partial synthesis from (-)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. Considering the good trypanosomicidal activity of HK and recalling that natural products are promising starting points for the discovery of novel potentially therapeutic agents, the aim of the present study was to investigate the (anti) mutagenic∕ genotoxic activities of HK. METHODS The mutagenic∕ genotoxic activities were… CONTINUE READING
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Comparative studies of the (anti) mutagenicity of Baccharis dracunculifolia and artepillin C by the bacterial reverse mutation test

  • FA Resende, CC Munari, +4 authors EA Varanda
  • Molecules
  • 2012
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