Mutagenic spectrum resulting from DNA damage by oxygen radicals.

@article{McBride1991MutagenicSR,
  title={Mutagenic spectrum resulting from DNA damage by oxygen radicals.},
  author={T J McBride and Bradley D. Preston and L. A. Loeb},
  journal={Biochemistry},
  year={1991},
  volume={30 1},
  pages={207-13}
}
Oxygen free radicals are highly reactive species that damage DNA and cause mutations. We determined the mutagenic spectrum of oxygen free radicals produced by the aerobic incubation of single-stranded M13mp2 DNA with Fe2+. The Fe2(+)-treated DNA was transfected into component Escherichia coli, and mutants within the nonessential lac Z alpha gene for beta… CONTINUE READING