Mutagenic effect of mercury (II) in eukaryotic cells.

  title={Mutagenic effect of mercury (II) in eukaryotic cells.},
  author={Maria Eugenia Ariza and Jane Holliday and Marshall V. Williams},
  journal={In vivo},
  volume={8 4},
Acute exposure of KB and Chinese hamster ovary cells (AS52) to low concentrations of mercury (II) results in a dose dependent binding of mercury to DNA. This binding of mercury (II) to the DNA occurs at concentrations of mercury that have little if any effect on glutatione levels or on superoxide dismutase activity. Mutational studies with AS52 cells demonstrated that concentrations (0.1 to 0.4 microM) of mercury (II) which were not cytotoxic caused an increase (1.7 to 3.1) in the frequency of… CONTINUE READING

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