Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota.

@article{Ishikawa2001MutagenicAN,
  title={Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota.},
  author={Tomoko Ishikawa and Naoya Uematsu and Toshimi Mizukoshi and Shigenori Iwai and Hiroko Iwasaki and Chikahide Masutani and Fumio Hanaoka and Ryu Ueda and Haruo Ohmori and Takeshi Todo},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 18},
  pages={15155-63}
}
cDNA sequences were identified and isolated that encode Drosophila homologues of human Rad30A and Rad30B called drad30A and drad30B. Here we show that the C-terminal-truncated forms of the drad30A and drad30B gene products, designated dpoletaDeltaC and dpoliotaDeltaC, respectively, exhibit DNA polymerase activity. dpoletaDeltaC and dpoliotaDeltaC efficiently bypass a cis-syn-cyclobutane thymine-thymine (TT) dimer in a mostly error-free manner. dpoletaDeltaC shows limited ability to bypass a 6-4… CONTINUE READING

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