Mutagenic and chemical modification of the ABA-1 allergen of the nematode Ascaris: consequences for structure and lipid binding properties.

@article{McDermott2001MutagenicAC,
  title={Mutagenic and chemical modification of the ABA-1 allergen of the nematode Ascaris: consequences for structure and lipid binding properties.},
  author={Lindsay C McDermott and Joyce L. Moore and Andrew Brass and Nicholas S. C. Price and Sharon M Kelly and Alan H Cooper and Malcolm W Kennedy},
  journal={Biochemistry},
  year={2001},
  volume={40 33},
  pages={9918-26}
}
The polyprotein allergens/antigens of nematodes (NPAs) are the only lipid binding proteins known to be produced as polyproteins. Cleavage of the large polyprotein precursors at regularly spaced proteinase cleavage sites produces 10 or 11 individual protein units of approximately 15 kDa. The sequences of these units are highly diverse within and between species, but there are five absolutely or strongly conserved amino acid positions (Trp15, Gln20, Leu42, Cys64, and Cys120). We have tested the… CONTINUE READING

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