Mutagenic analysis of the 5' arm of the influenza A virus virion RNA promoter defines the sequence requirements for endonuclease activity.

@article{Leahy2001MutagenicAO,
  title={Mutagenic analysis of the 5' arm of the influenza A virus virion RNA promoter defines the sequence requirements for endonuclease activity.},
  author={Michael B Leahy and D C Pritlove and Leo Lit Man Poon and George G. Brownlee},
  journal={Journal of virology},
  year={2001},
  volume={75 1},
  pages={134-42}
}
Short synthetic influenza virus-like RNAs derived from influenza virus promoter sequences were examined for their ability to stimulate the endonuclease activity of recombinant influenza virus polymerase complexes in vitro, an activity that is required for the cap-snatching activity of primers from host pre-mRNA. An extensive set of point mutants of the 5' arm of the influenza A virus viral RNA (vRNA) was constructed to determine the cis-acting elements which influenced endonuclease activity… CONTINUE READING

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