Mutagenic activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine


MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin, which can damage dopaminergic neurons. It causes symptoms resembling those observed in patients suffering from Parkinson’s disease, and hence this toxin is widely used in studies on animal models of this disorder. Mutagenicity of MPTP was also reported by some authors, but results obtained… (More)
DOI: 10.1007/BF03194604

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