Mutagenic/carcinogenic potential of DEHP and MEHP.

  title={Mutagenic/carcinogenic potential of DEHP and MEHP.},
  author={I. N. Tomita and Yutaka Nakamura and Naoto Aoki and Naoki Inui},
  journal={Environmental Health Perspectives},
  pages={119 - 125}
The mutagenic/carcinogenic activities of DEHP and MEHP were studied in bacteria and mammalian cells. MEHP but not DEHP exerted a dose-dependent DNA damaging effect to B. subtilis in Rec-assay. DEHP and MEHP showed mutagenic activities to S. typhimurium TA-100, with and without S-9 mix, respectively. MEHP produced not only the mutation in E. coli WP2B/r but also sister chromatid exchanges (SCE) in Chinese hamster V79 cells. It also induced 8AG/6TG-resistant gene mutations and chromosomal… CONTINUE READING