Mutagenesis studies of thyroxine binding to human serum albumin define an important structural characteristic of subdomain 2A.

Abstract

The familial dysalbuminemic hyperthyroxinemia (FDH) phenotype results from a natural human serum albumin (HSA) mutant, with histidine instead of arginine at amino acid position 218. This mutation results in an enhanced affinity for thyroxine. In our earlier study, site-directed mutagenesis and a yeast protein expression system were used to synthesize FDH… (More)

Topics

Cite this paper

@article{Petersen1997MutagenesisSO, title={Mutagenesis studies of thyroxine binding to human serum albumin define an important structural characteristic of subdomain 2A.}, author={C. Petersen and C E Ha and Krishna Harohalli and D. Park and Nadhipuram V. Bhagavan}, journal={Biochemistry}, year={1997}, volume={36 23}, pages={7012-7} }