Mutagenesis of the catalytic and cleavage site residues of the hypovirus papain-like proteases p29 and p48 reveals alternative processing and contributions to optimal viral RNA accumulation.

Abstract

The positive-stranded RNA genome of the prototypic virulence-attenuating hypovirus CHV-1/EP713 contains two open reading frames (ORF), each encoding an autocatalytic papain-like leader protease. Protease p29, derived from the N-terminal portion of ORF A, functions as a suppressor of RNA silencing, while protease p48, derived from the N-terminal portion of… (More)
DOI: 10.1128/JVI.01489-14

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Cite this paper

@article{Jensen2014MutagenesisOT, title={Mutagenesis of the catalytic and cleavage site residues of the hypovirus papain-like proteases p29 and p48 reveals alternative processing and contributions to optimal viral RNA accumulation.}, author={Kenneth S Jensen and Donald L. Nuss}, journal={Journal of virology}, year={2014}, volume={88 20}, pages={11946-54} }