Mutagenesis of highly conserved histidines in lecithincholesterol acyltransferase: identification of an essential histidine (His 377).

@article{Adimoolam1998MutagenesisOH,
  title={Mutagenesis of highly conserved histidines in lecithincholesterol acyltransferase: identification of an essential histidine (His 377).},
  author={S Adimoolam and Young Phil Lee and Ana Jonas},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={243 2},
  pages={337-41}
}
Lecithin-cholesterol acyltransferase (LCAT) is responsible for the formation of cholesterol esters in plasma and is implicated in the removal of excess cholesterol from peripheral tissues. It is generally accepted that the catalytic mechanism of LCAT is similar to that of serine proteases and lipases involving a Ser, a His, and an acidic amino acid residue… CONTINUE READING