• Corpus ID: 35970729

Mutagenesis at a complex locus in Drosophila with the monofunctional alkylating agent, ethyl methanesulfonate.

  title={Mutagenesis at a complex locus in Drosophila with the monofunctional alkylating agent, ethyl methanesulfonate.},
  author={John B. Jenkins},
  volume={57 4},
  • J. Jenkins
  • Published 1 December 1967
  • Biology
  • Genetics
use of chemical mutagens in Drosophila usually results in the production T:mutants which are composed of mutant and nonmutant tissue. Mutants of this type are referred to as mosaic or fractional, as opposed to the complete or whole body mutants so commonly found in studies of X-ray mutagenesis. For the detection of mosaic and complete mutants, as well as for general mutagenesis studies, the most frequently used genetic system is the sex-linked lethal system. The use of this system( has, however… 

Figures and Tables from this paper

On the interpretation of mutagenically induced mosaicism in Drosophila.
The experimental evidence that must be generated, and the methodology that can be used to analyze this evidence, are clarified to render the effect of EMS on D. melanogaster more accurate, or if it is of interest to conduct a similar analysis for other mutagens that cause a significant degree of mosaicism.
Mutagenesis at the cinnabar locus in Drosophila melanogaster
Over 80% of the F1 phenotypic mutants could be classified as mosaics, which indicates that cinnabar can be autonomous under certain conditions, and the failure to isolate mutations in possible regulatory function is discussed.
Mutagenesis at Five Pteridine Pathway Loci In Drosophila melanogaster: Genetic and Biochemical Characterization
The low mutagenesis frequencies and the lack of some metabolites for Hnr and se mutants suggest an important role of these mutants in the pteridine pathway.


Chemically Induced Somatic and Gonadal Mosaicism in Drosophila. I. Sex-Linked Lethals.
The HeHE sex-linked lethal test provides an objective, quantitative approach to Tmutagenesis in Drosophila and demonstrates the capacity for inducing mosaicism in F, female gonads.
A structural analysis of the dumpy region and its bearing on the concept of pseudoallelism
  • Nature
  • 1966
Ethyl niethanesulfonateinduced reversion of phage T 4 rZZ mutants
  • Genetics
  • 1963
The delayed origin of mutants induced by exposure of extracellular phage T4 to ethyl methane sulfonate.
  • D. Green, D. R. Krieg
  • Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1961