Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes.

@article{Tanner1997MutagenesisAC,
  title={Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes.},
  author={Michihiko Tanner and Emily M. Anderson and Robin Ray Gutell and Thomas R Cech},
  journal={RNA},
  year={1997},
  volume={3 9},
  pages={
          1037-51
        }
}
Tertiary interactions are important in the higher-order folding of catalytic RNAs. Recently, a base triple, joining the two major domains of the catalytic core, was determined in group I introns from the cyanobacterium Anabaena PCC7120 and the eukaryote Tetrahymena thermophila. This base triple involves the fifth base pair of P4 and the fifth base of the single-stranded region J8/7. We made base pair and single-nucleotide substitutions in the fifth base pair of P4, a G-C in the wild-type… CONTINUE READING

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