Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids

@inproceedings{Nakabeppu2006MutagenesisAC,
  title={Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids},
  author={Yusaku Nakabeppu and Kunihiko Sakumi and Katsumi Sakamoto and Daisuke Tsuchimoto and Teruhisa Tsuzuki and Yoshimichi Nakatsu},
  booktitle={Biological chemistry},
  year={2006}
}
Abstract Genomes and their precursor nucleotides are highly exposed to reactive oxygen species, which are generated both as byproducts of oxygen respiration or molecular executors in the host defense, and by environmental exposure to ionizing radiation and chemicals. To counteract such oxidative damage in nucleic acids, mammalian cells are equipped with three distinct enzymes. MTH1 protein hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-2′-deoxyguanosine triphosphate and 2… Expand
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