Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids

  title={Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids},
  author={Y. Nakabeppu and K. Sakumi and K. Sakamoto and D. Tsuchimoto and T. Tsuzuki and Y. Nakatsu},
  booktitle={Biological chemistry},
  • Y. Nakabeppu, K. Sakumi, +3 authors Y. Nakatsu
  • Published in Biological chemistry 2006
  • Biology, Medicine
  • Abstract Genomes and their precursor nucleotides are highly exposed to reactive oxygen species, which are generated both as byproducts of oxygen respiration or molecular executors in the host defense, and by environmental exposure to ionizing radiation and chemicals. To counteract such oxidative damage in nucleic acids, mammalian cells are equipped with three distinct enzymes. MTH1 protein hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-2′-deoxyguanosine triphosphate and 2… CONTINUE READING
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