Mutagenesis analysis of the NS2B determinants of the Alkhurma virus NS2B-NS3 protease activation.

@article{Pastorino2006MutagenesisAO,
  title={Mutagenesis analysis of the NS2B determinants of the Alkhurma virus NS2B-NS3 protease activation.},
  author={Boris A. M. Pastorino and Christophe Nicolas Peyrefitte and Marc Grandadam and Maxime C E Thill and Hugues J. Tolou and Ma{\"e}l Bessaud},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 11},
  pages={3279-83}
}
Alkhurma virus (ALKV) is a tick-borne class 4 flavivirus responsible for several human cases of haemorrhagic fever in Saudi Arabia, with no specific treatment currently available. The viral RNA encodes a serine protease (NS2B-NS3), essential for virus replication in infected cells, that constitutes an attractive target for antiviral compounds. In an attempt to identify residues and motifs on NS2B that are necessary for protease activity of the ALKV NS2B-NS3 complex, a series of modified NS2B… CONTINUE READING