Mutagenesis Reveals a Role for ABP/GRIP Binding to GluR2 in Synaptic Surface Accumulation of the AMPA Receptor

@article{Osten2000MutagenesisRA,
  title={Mutagenesis Reveals a Role for ABP/GRIP Binding to GluR2 in Synaptic Surface Accumulation of the AMPA Receptor},
  author={Pavel Osten and Latika Khatri and J. L. Beato P{\'e}rez and Georg K{\"o}hr and Guenter Giese and Christopher Daly and Torsten W Schulz and Allen K. Wensky and Laveria M Lee and Edward Benjamin Ziff},
  journal={Neuron},
  year={2000},
  volume={27},
  pages={313-325}
}
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References

SHOWING 1-10 OF 96 REFERENCES
NSF Binding to GluR2 Regulates Synaptic Transmission
Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP
Characterization of the Glutamate Receptor-Interacting Proteins GRIP1 and GRIP2
TLDR
Results suggest that GRIP1 and GRIP2 are AMPA receptor binding proteins potentially involved in the targeting of AMPA receptors to synapses, as well as in early neuronal development.
Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1
Association of AMPA Receptors with a Subset of Glutamate Receptor-Interacting Protein In Vivo
TLDR
Findings support a role for GRIP in the synaptic anchoring of AMPA receptors but also suggest that GRIP has additional functions unrelated to the binding of AMpa receptors.
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
TLDR
GRIP is a new member of the PDZ domain-containing protein family which has seven PDZ domains and no catalytic domain and appears to serve as an adapter protein that links AMPA receptors to other proteins and may be critical for the clustering of AMPA receptor at excitatory synapses in the brain.
Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction
Essential Role for dlg in Synaptic Clustering of Shaker K+ Channels In Vivo
TLDR
It is demonstrated for the first time that DLG plays an important role in synaptic organization in vivo that correlates with its ability to bind directly to specific membrane proteins of the synapse.
Synaptic Clustering of Fasciclin II and Shaker: Essential Targeting Sequences and Role of Dlg
The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs
...
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