Mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycyclic hydrocarbons.

Abstract

The relationship between carcinogenesis and mutagenesis in mammalian cells has been determined with 10 polycyclic hydrocarbons with different degrees of carcinogenicity. Mutagenesis was determined in Chinese hamster cells with genetic markers that affect the surface membrane, nucleic-acid synthesis, and protein synthesis. The mutations were characterized by… (More)

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Cite this paper

@article{Huberman1976MutabilityOD, title={Mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycyclic hydrocarbons.}, author={Eliezer Huberman and Leo Sachs}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1976}, volume={73 1}, pages={188-92} }