MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

@article{Guan1998MutYCC,
  title={MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily},
  author={Yue Guan and Raymond C. Manuel and Andrew S. Arvai and Sudip S. Parikh and Clifford D. Mol and Jeffrey H. Miller and R. Stephen Lloyd and John A. Tainer},
  journal={Nature Structural Biology},
  year={1998},
  volume={5},
  pages={1058-1064}
}
The DNA glycosylase MutY, which is a member of the Helix-hairpin-Helix (HhH) DNA glycosylase superfamily, excises adenine from mispairs with 8-oxoguanine and guanine. High-resolution crystal structures of the MutY catalytic core (cMutY), the complex with bound adenine, and designed mutants reveal the basis for adenine specificity and glycosyl bond cleavage chemistry. The two cMutY helical domains form a positively-charged groove with the adenine-specific pocket at their interface. The Watson… 

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Crystallizing thoughts about DNA base excision repair.

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Flipping Duplex DNA Inside Out

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