MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

  title={MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant
  author={Asmita Patel and Dominick G. A. Burton and Katherine M. Halvorsen and Wayne Balkan and Teresita Reiner and C Perez-stable and Alexander A. Cohen and Anisleidys Mu{\~n}oz and Maria G. Giribaldi and Samer Singh and David J Robbins and Dao M. Nguyen and Priyamvada Rai},
Oncogenic RAS promotes production of reactive oxygen species (ROS), which mediate pro-malignant signaling but can also trigger DNA damage-induced tumor suppression. Thus RAS-driven tumor cells require redox-protective mechanisms to mitigate the damaging aspects of ROS. Here, we show that MutT Homolog 1 (MTH1), the mammalian 8-oxodGTPase that sanitizes oxidative damage in the nucleotide pool, is important for maintaining several KRAS-driven pro-malignant traits in a nonsmall cell lung carcinoma… CONTINUE READING
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Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2013

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