MutSα and MutLα immunoexpression analysis in diagnostic grading of oral epithelial dysplasia and squamous cell carcinoma.

@article{Jessri2015MutSAM,
  title={MutSα and MutLα immunoexpression analysis in diagnostic grading of oral epithelial dysplasia and squamous cell carcinoma.},
  author={Maryam Jessri and Andrew J Dalley and Camile S Farah},
  journal={Oral surgery, oral medicine, oral pathology and oral radiology},
  year={2015},
  volume={119 1},
  pages={
          74-82
        }
}
OBJECTIVES This study explored the expression of DNA mismatch repair (MMR) proteins in a range of oral biopsies. We further evaluated the significance of MMR protein expression combined with basic demographic data in differentiating grades of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). STUDY DESIGN Immunohistochemical expression of MutSα (hMLH1 and hPMS2) and MutLα (hMSH2 and hMSH6) were compared in 98 formalin-fixed paraffin embedded oral biopsies: 21 normal, 24… CONTINUE READING
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